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Real members of myHIVteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myHIVteam Member asked a question 💭
Barrie, ON

I'm very curious if there is a new injectable for people living with HIV?I'm on Cabenuva, which is the monthly shot.

December 15, 2025
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A myHIVteam Member

There is a new shot out, not sure if it's in Canada or the United States. But awhile back there was a twice yearly shot coming out, but I don't remember which country.

December 15, 2025
A myHIVteam Member

Cabenuva is a two injection every two months.

Internet Source:
(ALWAYS TALK TO YOUR PROVIDER(S) FIRST)

Yes, besides Cabenuva (cabotegravir/rilpivirine), other injectable HIV medicines available or in development include Lenacapavir (Sunlenca/Yeztugo) for treatment/prevention (dosed every 6 months) and Ibalizumab (Trogarzo), plus ongoing trials for combinations like Sunlenca + bNAbs, showing a shift to less frequent, more convenient long-acting options.
Currently Approved Injectable Medications (Beyond Cabenuva):
Lenacapavir (Sunlenca/Yeztugo): A new class (capsid inhibitor) that can be given as a twice-yearly injection for treatment (with other drugs) or prevention (Yeztugo), offering significant convenience.
Ibalizumab (Trogarzo): An antibody treatment (ibalizumab) used for heavily treatment-resistant HIV, administered less frequently than daily pills.
In Development & Future Possibilities:
Lenacapavir Combinations: Trials are exploring combining Lenacapavir with other long-acting agents for even longer intervals (e.g., every 6 months).
Broadly Neutralizing Antibodies (bNAbs): Combinations with Sunlenca are being tested for potential twice-yearly injections.
Novel Drug Candidates: New drugs like VH-184 and VH-499 are showing promise in trials, potentially leading to future long-acting injectables.
Key Trend: The field is moving towards fewer injections (monthly, every few months, or even twice yearly) with drugs like Lenacapavir, offering a major shift from daily oral regimens.

December 15, 2025 (edited)
myHIVteam

Are there new injectable options beyond Cabenuva for treating HIV?

Yes, there are newer injectable options available! While you're currently on Cabenuva (the monthly shot), there are a couple of additional injectable treatments approved for people living with HIV:

Sunlenca (lenacapavir) - This is a twice-yearly injection Show Full Answer

Are there new injectable options beyond Cabenuva for treating HIV?

Yes, there are newer injectable options available! While you're currently on Cabenuva (the monthly shot), there are a couple of additional injectable treatments approved for people living with HIV:

Sunlenca (lenacapavir) - This is a twice-yearly injection approved in December 2022. It's a capsid inhibitor that works differently from other HIV medications. You'll start with an oral version for about a week to make sure you tolerate it well, then move to just two injections per year.

Trogarzo (ibalizumab-uiyk) - Another injectable option that's also available.

However, both Sunlenca and Trogarzo are specifically intended for people who have developed resistance to other HIV medications. They also need to be taken alongside other HIV medications (usually daily pills), which means you wouldn't get the same convenience benefit as Cabenuva alone.

Since you're doing well on Cabenuva, these newer options might not be necessary for you unless you develop resistance. But it's great that more choices are becoming available! If you're curious about whether any of these might work better for your situation, definitely chat with your healthcare provider.

December 15, 2025

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