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Real members of myHIVteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Switching to Dovato from Biktarvy

A myHIVteam Member asked a question 💭
Williamsburg, VA

I'm switching from Biktarvy to Dovato as I talked to my doctor about wanting kidney and bone sparing antiretrovirals. I see that 3TC is a component of Dovato; I'm concerned about possibly developing neuropathy on it. Does anyone have experiences with taking Dovato?

November 9, 2025
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A myHIVteam Member

I have experience with Dovato. Up until two days ago, I had been on Dovato for four years. I'm back on Biktarvy now due to side effects, including neuropathy, I suspected were due to Dovato. It's only been a couple days, but I DO feel like my neuropathy is better since switching.

November 9, 2025
A myHIVteam Member

This begs a question. Is Dovato the safer option when low eGFR labs show up right after starting Biktarvy?

November 9, 2025
myHIVteam

What are your concerns about switching from Biktarvy to Dovato, particularly regarding neuropathy risk with 3TC (lamivudine)?

It's great that you're working with your doctor on a kidney and bone sparing option. Dovato (dolutegravir plus lamivudine) is indeed recognized as an alternative treatment option for some people Show Full Answer

What are your concerns about switching from Biktarvy to Dovato, particularly regarding neuropathy risk with 3TC (lamivudine)?

It's great that you're working with your doctor on a kidney and bone sparing option. Dovato (dolutegravir plus lamivudine) is indeed recognized as an alternative treatment option for some people with HIV.

Regarding your concern about neuropathy with lamivudine (3TC): lamivudine is generally well-tolerated and neuropathy is not commonly associated with this medication. Neuropathy has been more frequently linked to older HIV medications that aren't typically used in current first-line treatments.

Important considerations for Dovato:

Your healthcare team will need to ensure this combination is right for you. Dovato may not be suitable for people with very high viral loads or those with hepatitis B co-infection.

It's essential to take your medication exactly as prescribed and keep up with regular monitoring appointments. If you experience any new symptoms after switching, contact your healthcare provider promptly.

Since you're making this switch under medical supervision, your doctor can monitor how you respond and make adjustments if needed.

November 9, 2025

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