Self-injecting cholesterol-lowering medications like Repatha (evolocumab) involves a simple subcutaneous injection (under the skin) using an auto-injector pen or prefilled syringe every 2 to 4 weeks.
I hated it, maybe men have better luck with this. I could not see over my boobs to give myself a shot in the stomach and went off it. When I worked in my ID office I had nurses giving me this shot in the back of my arm - which I can not reach on my own either.

Yes, cholesterol-lowering shots do exist, and talking to your primary care doctor is definitely the best first step.
What Are These Injections?
These medications are a newer class of treatment designed to drastically lower LDL ("bad") cholesterol. They work primarily by targeting a specific protein in the liver (called PCSK9) to help your body clear bad cholesterol from your bloodstream far more effectively.
There are two main types of injectable cholesterol medications available:
PCSK9 Inhibitors (like Repatha/evolocumab or Praluent/alirocumab):
These are self-administered shots (similar to an EpiPen or insulin pen) that you give yourself at home, usually once or twice a month.
siRNA Therapy (like Leqvio/inclisiran):
This is a newer type of injection that stops the production of the PCSK9 protein altogether. It is usually administered by a healthcare provider in an office setting. After initial starter doses, it only needs to be given twice a year.
Who Are These Shots For?
Daily oral medications called statins remain the standard first-line treatment for high cholesterol because they are well-studied, highly effective, and widely affordable. Doctors generally consider injectable treatments for specific situations, such as: Statin Intolerance: People who experience severe side effects (like significant muscle pain) from standard statin pills.
High-Risk Individuals: People with diagnosed heart disease or genetic high cholesterol (Familial Hypercholesterolemia) whose LDL levels remain dangerously high even on the maximum dose of daily statins.
Questions to Ask Your DoctorWhen you talk to your healthcare provider, you might want to bring up the following:
"Are my current cholesterol numbers high enough to warrant changing my treatment plan?"
"Would a simple daily statin pill be the best starting place, or am I a candidate for an injectable medication?"
"What lifestyle changes (diet, exercise) should I be combining with my treatment?"
"If an injection is appropriate, will my health insurance cover it?" (Injectables can be expensive, so doctors often need to submit prior authorizations demonstrating that standard pills aren't enough).
Starting with your doctor will allow them to check your recent lipid panel, review your family history, and find the safest, most effective approach for you.

Yes I’m on one - I can’t take any statins due to severe side effects