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Real members of myHIVteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myHIVteam Member asked a question 💭
San Bernardino, CA

I first started on testosterone injections. Then was switched to the gel (once a day). Then was told testosterone was high so I stopped. I had them recheck levels this month and found I'm low again. My question is: to those on injections, do you inject your quad (upper leg) or somewhere else? I used my quad, but I never quite felt 100% comfortable doing it. But I think it worked better than the gel. Anyone have experience with both injections and gel? I'm thinking I want back in injections as I… read more

October 28, 2025 (edited)
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Answer Summary

Members shared diverse experiences with testosterone replacement therapy, with most finding injections more effective than gel for maintaining... Read more

Members shared diverse experiences with testosterone replacement therapy, with most finding injections more effective than gel for maintaining stable levels, though some experienced complications like polycythemia (excess red blood cells) that required dosage adjustments. Several members described their preferred injection sites, with the upper leg (quad) being the most practical for self-administration, though some also use the shoulder or upper buttock, noting that reaching the buttock can be challenging when living alone. A recurring theme was the importance of regular monitoring and working closely with doctors to find the right method and dosage, as individual responses varied widely, with some thriving on gel while others needed injections to stay within healthy testosterone ranges.

A myHIVteam Member

I did injections for years, before switching to topical gel. I was never within range when my level was tested on injections, but I am bang on with two pumps daily every time I am tested. You don't want your levels to swing wide because that is how you lose hair, get gynecomastia lose your testicles, etc. Things you probably want to avoid.🤠

October 29, 2025
A myHIVteam Member

Please go over your Medicare insurance plan because I'm also on Medicare (Humana)
and they fill my HIV regimen which is covered. You may also look at the Ryan White program because they may cover it as well.

October 30, 2025 (edited)
A myHIVteam Member

I do inject my butt

October 28, 2025
A myHIVteam Member

Hey there. I have experience with both the gel and the injection.
I started on the gel, once daily, in 2010. It did increase my testosterone to well within acceptable levels. However, in 2024, for whatever reason, my testosterone plummeted to below the lower end of the healthy range. So at that time my doctor switched me to the injection. The injection brought my testosterone way too high at . 5 milliliters and I got polycythemia, which is too many red blood cells in short. So my HIV doctor suggested that I reduce to 4 ml and that did bring my testosterone down just a little bit but well within the high end of the range and did bring my red blood cell count and hemoglobin down. All good.
Depending upon my next Lab work, I may have to reduce even more, but I feel confident that we will get my red blood cells where they need to be simply by adjusting my testosterone injection.
It's not surprising to me that your testosterone went down when you switched to the gel. Almost always, the topical gel is not going to increase testosterone levels as much as an injection. I take my 4 ml once a week. I inject myself in the upper to middle part of my quad. The only other recommended injection site is the upper buttock. However, if you live alone that is very difficult to do.

November 4, 2025
A myHIVteam Member

I just came back from seeing my doctor yesterday trying to figure out which route we are going with the testosterone therapy. I’ve tried patches they burned my skin. I tried the pellets, they started coming out. The gel was just kind of messy for me, I think it might have been the process that I had an issue with. I did try the prefilled injectables and they seem to work but my insurance that I had at the time covered them but now that I’m on Medicare, they don’t cover them. So she gave me some samples of what I was taking before and then in three months, we’ll see how it goes because my levels were extremely low 119.

October 30, 2025

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