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COMBINATION DRUG
Triumeq and Triumeq PD (abacavir/dolutegravir/lamivudine) are prescription medications approved by the U.S. Food and Drug Administration (FDA) to treat human immunodeficiency virus type 1 (HIV-1) infection in adults and children aged 3 months and older who weigh at least 6 kilograms.
These insights are based on 612 comments about Triumeq and Triumeq PD from myHIVteam members. These are the experiences of a small number of people and are not meant to be medical advice.
One pill once daily feels simple and easier to stick with.
Many describe reaching or maintaining an undetectable viral load.
Long-term use feels sustainable for some, with few or no side effects.
Nausea, diarrhea, headaches, fatigue, and insomnia come up often.
Antacids, calcium, iron, and some vitamins require careful timing.
Cost, copays, refills, and insurance coverage can add extra stress.
Triumeq and Triumeq PD are combination medicines used to treat HIV-1. They contain three medicines: abacavir, dolutegravir, and lamivudine.
These medicines act on two enzymes that HIV needs to reproduce. Dolutegravir blocks an enzyme called integrase. Abacavir and lamivudine block an enzyme called reverse transcriptase. These actions interfere with the HIV replication process.
Triumeq and Triumeq PD are used to treat HIV-1 infection in adults and children who are at least 3 months old and weigh at least 6 kilograms.
HIV-1 is the virus that causes acquired immune deficiency syndrome (AIDS).
Triumeq or Triumeq PD alone is not recommended for people who have certain changes linked to resistance to integrase inhibitors or who are suspected of having resistance to this type of HIV medicine.
Triumeq and Triumeq PD are taken by mouth and may be taken with or without food. Triumeq tablets should not be chewed, cut, or crushed.
Triumeq PD tablets for oral suspension must be mixed with drinking water before they are given. They should not be chewed, cut, crushed, or swallowed whole.
If you take antacids, laxatives, or other medicines that contain aluminum or magnesium, take Triumeq or Triumeq PD at least two hours before or six hours after these medicines.
If you take calcium or iron supplements, including multivitamins that contain calcium or iron, you may take them at the same time as Triumeq or Triumeq PD if you take them with food. If you take Triumeq or Triumeq PD without food, take it at least two hours before or six hours after the supplement.
Triumeq tablets and Triumeq PD tablets for oral suspension are different forms of the medicine. They should not be substituted for each other on a milligram-per-milligram basis.
For adults, the recommended dose is one Triumeq tablet once daily. Each tablet contains 600 milligrams of abacavir, 50 milligrams of dolutegravir, and 300 milligrams of lamivudine. Triumeq PD should not be used in adults.
Children who weigh at least 25 kilograms also take one Triumeq tablet once daily.
Triumeq PD is used in children who weigh 6 kilograms to less than 25 kilograms. Each Triumeq PD tablet contains 60 milligrams of abacavir, 5 milligrams of dolutegravir, and 30 milligrams of lamivudine. The number of tablets taken once daily is based on body weight:
Triumeq PD is not recommended for people who weigh 25 kilograms or more.
When Triumeq or Triumeq PD is taken with certain other medicines, an additional dose of dolutegravir may need to be taken 12 hours after the Triumeq or Triumeq PD dose.
This information is based on prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 612 comments about Triumeq and Triumeq PD from myHIVteam members.Members who use Triumeq often say that routines, side effect tracking, and regular communication with a doctor can make treatment feel more manageable. Many also mention practical ways to handle nausea, sleep problems, lab changes, and cost concerns while staying consistent with treatment.
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In clinical studies of Triumeq and Triumeq PD, the most common moderate to severe side effects occurred in about 2 percent or more of people. These include:
Triumeq can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
ViiV Healthcare, the manufacturer of Triumeq and Triumeq PD, offers the ViiVConnect Savings Card. Eligible people with commercial insurance may pay as little as $0 per prescription fill.
The ViiVConnect Savings Card also offers reimbursement for eligible copay costs if your pharmacy can’t process the card.
To learn more, visit the ViiVConnect Savings Card website or call 866-279-4705.
Before starting Triumeq or Triumeq PD, your doctor will test you for a gene variation called HLA-B*5701 and for HBV infection.
Before taking Triumeq or Triumeq PD, tell your doctor if you:
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.
Triumeq and Triumeq PD can interact with other medicines. Some medicines can lower the amount of dolutegravir in your body and may make treatment less effective.
Do not take Triumeq or Triumeq PD if you:
Do not miss doses or let your supply of Triumeq or Triumeq PD run out. Missing doses may allow the amount of HIV-1 in your blood to increase and may make the virus harder to treat.
If you miss a dose of Triumeq or Triumeq PD, take it as soon as you remember. Do not take two doses at the same time or take more than your prescribed dose.
If you are pregnant or plan to become pregnant, talk with your doctor about the benefits and risks of taking Triumeq during pregnancy.
A pregnancy registry tracks pregnancy outcomes in people exposed to Triumeq. Healthcare providers can register pregnancies by visiting the Antiretroviral Pregnancy Registry or calling 1-800-258-4263.
If you are breastfeeding or plan to breastfeed, talk with your healthcare provider. Abacavir, dolutegravir, and lamivudine are present in human milk. Possible risks of breastfeeding include:
These answers are fact-checked by our editorial staff.
How effective are Triumeq and Triumeq PD for HIV?
In a 144-week study of adults starting HIV treatment, 71 percent of people taking dolutegravir plus abacavir and lamivudine had an HIV-1 RNA level below 50 copies per milliliter. This compared with 63 percent of people taking Atripla, another HIV treatment used in the study.
In the same study, the average number of CD4-positive cells, which are immune cells that help the body fight infections, increased by 378 cells per cubic millimeter.
In a pediatric study, 79 percent of children had HIV-1 RNA below 50 copies per milliliter at 48 weeks. Also, 95 percent had HIV-1 RNA below 200 copies per milliliter.
How long do Triumeq and Triumeq PD take to work for HIV?
The studies do not give one exact timeline for when Triumeq or Triumeq PD starts working.
In clinical studies, HIV-1 RNA levels were measured at specific time points, including 48 weeks and 144 weeks.
What other medicines can interact with Triumeq or Triumeq PD?
Triumeq and Triumeq PD can interact with several medicines and supplements. These include:
Some interactions can change how much medicine is in your body. Some combinations may need different timing or an extra dose of dolutegravir.
Medicines that contain aluminum or magnesium should be taken at a different time from Triumeq or Triumeq PD. Take Triumeq or Triumeq PD at least two hours before or six hours after these medicines.
Calcium or iron supplements may be taken at the same time as Triumeq or Triumeq PD if you take them with food. If you take Triumeq or Triumeq PD without food, take it at least two hours before or six hours after the supplement.
Tell your healthcare provider about all the medicines, vitamins, and supplements you take before starting Triumeq or Triumeq PD.
On myHIVteam, people share their experiences with HIV, get advice, and find support from others who understand.
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