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COMBINATION DRUG
Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat human immunodeficiency virus type 1 (HIV-1) infection in adults and children who weigh at least 25 kilograms.
These insights are based on 1,048 comments about Genvoya from myHIVteam members. These are the experiences of a small number of people and are not meant to be medical advice.
One pill once daily feels simple and manageable.
Viral load often becomes undetectable and stays suppressed.
CD4 counts often improve over time.
Weight gain is a frequent concern and can feel hard to reverse.
Drug interactions can complicate use with other medicines.
Stopping suddenly can be risky with hepatitis B coinfection.
Genvoya is a type of antiretroviral medicine. It is used to treat HIV-1. It contains medicines that block integrase and reverse transcriptase, which HIV-1 uses to make more copies of itself.
Doctors prescribe Genvoya as a complete HIV-1 treatment for adults and children who:
HIV-1 is the virus that causes acquired immune deficiency syndrome (AIDS).
Genvoya is taken by mouth once daily with food.
The recommended dose is one tablet once daily with food. Each tablet contains:
Genvoya is not recommended for people with severe liver and kidney problems. Adults receiving chronic hemodialysis should take Genvoya after hemodialysis on dialysis days.
This information is based on prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 1,048 comments about Genvoya from myHIVteam members.Members who use Genvoya often say that routines, symptom tracking, and regular check-ins with a doctor matter most. Many members also suggest speaking up early about side effects, lab changes, medication timing, and cost or coverage issues, since experiences with Genvoya can vary a lot from person to person.
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In clinical studies of Genvoya, the most common side effects occurred in about 5 percent to 11 percent of people. These include:
Genvoya can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Gilead Sciences, Inc, the manufacturer of Genvoya, offers the Gilead Advancing Access Co-pay Savings Program. Eligible people with commercial insurance may pay as little as $0 per month. If you have government insurance or no insurance, the program also provides information about other financial assistance options that may be available.
The Gilead Advancing Access Program also offers help understanding insurance coverage, answering insurance-related questions, and exploring available coverage options.
To learn more, visit the Gilead Advancing Access Program website or call 800-226-2056.
Before starting Genvoya, your healthcare provider will test you for HBV infection.
Your healthcare provider will also check your kidney function before or when you start Genvoya and during treatment. Tests include serum creatinine, estimated creatinine clearance, urine glucose, and urine protein. If you have chronic kidney disease, your serum phosphorus should also be checked.
Tell your doctor if you have any allergies to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate or any ingredients in Genvoya.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.
Do not take Genvoya with:
Do not stop taking Genvoya or let your supply run out without talking with your healthcare provider. Missing doses can allow HIV-1 to increase and may make the virus harder to treat.
If you are pregnant or planning to become pregnant, tell your doctor. Genvoya should not be started during pregnancy and is not recommended during pregnancy.
A pregnancy exposure registry monitors pregnancy outcomes in people exposed to Genvoya. Healthcare providers can register pregnancies by visiting the Antiretroviral Pregnancy Registry or calling 800-258-4263.
Do not breastfeed while taking Genvoya. HIV-1 can pass to a baby through breast milk. At least one medicine in Genvoya can pass into human breast milk, and it is not known whether all of the other medicines can. Breastfeeding may also cause drug resistance in a baby with HIV-1 or side effects in a breastfed baby.
These answers are fact-checked by our editorial staff.
How effective is Genvoya for HIV?
In two studies of adults starting HIV-1 treatment, 84 percent of people taking Genvoya had very low levels of HIV in their blood at week 144, compared with 80 percent of people taking Stribild.
People taking Genvoya also had an average increase of 326 CD4-positive cells per cubic millimeter. CD4-positive cells are immune cells that HIV can damage.
In another study of adults whose HIV was already well controlled, 93 percent of people who switched to Genvoya still had very low levels of HIV in their blood at week 96.
How long does Genvoya take to work for HIV?
The study does not give an exact amount of time for Genvoya to start working. Instead, clinical studies measured viral suppression at set time points.
In adults starting HIV-1 treatment, results were measured at weeks 48 and 144. In adolescents ages 12 to less than 18 years who were starting treatment, 92 percent had HIV-1 RNA below 50 copies per milliliter at week 48.
In children ages 6 to less than 12 years whose HIV-1 was already suppressed, 98 percent remained suppressed at week 48.
What tests or monitoring are needed with Genvoya for HIV?
Before or when starting Genvoya, people should be tested for HBV infection.
Before or when starting treatment and during treatment on a schedule chosen by the healthcare provider, monitoring includes:
On myHIVteam, people share their experiences with HIV, get advice, and find support from others who understand.
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