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Real members of myHIVteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
August 16, 2025
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A myHIVteam Member

Thats something you need to discuss with your negative wife. Science can't help you with that one.

August 18, 2025
myHIVteam

For PrEP to be effective, you need to take it consistently for a specific period before engaging in sexual activity:

• For anal sex: Take PrEP for 7 consecutive days before sexual activity
• For vaginal sex: Take PrEP for 20 consecutive days before sexual activity
• For injectable PrEP: Protection begins about 1 day after Show Full Answer

For PrEP to be effective, you need to take it consistently for a specific period before engaging in sexual activity:

• For anal sex: Take PrEP for 7 consecutive days before sexual activity
• For vaginal sex: Take PrEP for 20 consecutive days before sexual activity
• For injectable PrEP: Protection begins about 1 day after first injection for some people, with almost everyone protected within 7 days It's important to note that when the HIV-positive partner maintains consistent antiretroviral therapy (ART) and achieves an undetectable viral load, the risk of transmission becomes effectively zero. Regular testing and open communication with healthcare providers is essential for both partners to maintain safety in a serodiscordant relationship.

August 16, 2025

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