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Odefsey Side Effects
A myHIVteam Member asked a question 💭

Is anyone here on Odefsey? If yes, what types of side effects are you having? I have WAY more side effects on this than I did on Complera...

posted January 27, 2017 (edited)
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A myHIVteam Member

I have also been on Odefsey since it was released May 2016--they had to add the drug to Cigna Tel-Drug's systems to fill my mail-order prescriptiom--and I have experienced no side effects whatsoever. I had been off meds since Oct 2005 as part of NIH's longterm non-progressor study, but my immune system appeared to have lost control of the virus early last year. My last regimen had included Truvada; so, I was eager to use a single-tablet regimen, while I also wanted to avoid the booster cobicistat that appears to elevate cardiovascular disease risk.
If you are experiencing gastrointestinal issues, try taking it after a couple mouthfuls of a meal. Getting stomach acid going seems to help those who take Truvada and experience stomach discomfort at first. Others find discomfort goes away after a week or two; and it appears to be the binders in the tablet, not the active drugs.

posted March 15, 2017
A myHIVteam Member

I've been on it for a year and I have had some sleep issues and depression issues as well. But no other side effects.

posted February 19, 2021
A myHIVteam Member

No side effects here been taking for 2 yrs

posted October 3, 2018
A myHIVteam Member

MaryJane, that sounds like a hypersensitivity reaction to the rilpivirine component. It's rare, but potentially life-threatening. I hope that your doc is working with you!

posted March 22, 2017
A myHIVteam Member

Well I have been on Odefsey for only 2 months and holy hell! I am calling my doc tomorrow! The side effects are horrible! Are you having hot flashes? Dizziness? I don't like this feeling!🙃

posted March 20, 2017

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