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Yes, IRIS (Immune Reconstitution Inflammatory Syndrome) can occur when switching HIV treatments, not just when starting for the first time. Any ART that strengthens the immune system can potentially trigger IRIS — and Cabenuva is no exception.

IRIS happens when your immune system starts recovering and begins fighting Show Full Answer

Yes, IRIS (Immune Reconstitution Inflammatory Syndrome) can occur when switching HIV treatments, not just when starting for the first time. Any ART that strengthens the immune system can potentially trigger IRIS — and Cabenuva is no exception.

IRIS happens when your immune system starts recovering and begins fighting infections it previously couldn't. This can make you feel temporarily worse, even though your treatment is actually working. Some key things to know about IRIS risk:

- It most commonly appears within the first 4 to 8 weeks of starting or changing treatment
- People with a low CD4 count (under 100) are at higher risk
- Having had an opportunistic infection before switching also increases risk
- A strong, rapid response to treatment can also be a risk factor

The good news is that IRIS usually means your immune system is getting stronger — which is exactly what you want! If you start feeling unwell in the first few months on Cabenuva, it's important to contact your doctor right away. They will likely keep you on your treatment, as continuing it helps your immune system grow stronger. Never stop your medication without speaking to your doctor first.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

IRIS in HIV: 7 Facts To Know